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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Thu Sep 26, 2013 10:03 am 
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Location: West Central Fl.
hi saw a phrase and checked and led me to these web sites.

http://samhsa.gov/data/NSDUH/2012SummNa ... 12.htm#lot

http://samhsa.gov/data/NSDUH/2012SummNa ... m#Tab1.12B

digging leads to lots of info. One item was that people born between 1957 -1961 were the most pot users in their life times. but had one of the lowest uses of pot in the last month or year numbers are like this.
age 2011 2012 last month averages

50-54 57.3 56.7 7.9 8.0 4.9 5.1

what happened to addiction?
another thing was that illegal drugs==prescription w/out a prescription== was lot worse than Pot in numbers being used.
also the number of teens using pot has went down in 2012 to 7% or there abouts fron 2002 when was 9.4% lots of charts lee


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Mon Sep 30, 2013 8:09 am 
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Hi
I remember reading that Feds said they were not going to cause problems for Wash. And Colo. but the moneys could not be put into federal banks , or those controlled by the federal reserve . It caused a lot of tax collectors to get cash for their taxes from these businesses. Now this.
http://www.fool.com/investing/general/2 ... -with.aspx

Seems as if The Bank of America is still not afraid of U.S.Government. Bank says if there is money here we want a share. B OF A is big. Feds will back down.


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Mon Oct 21, 2013 3:22 pm 
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Location: West Central Fl.
http://news.yahoo.com/uruguay-official- ... 36333.html


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Thu Nov 21, 2013 8:13 am 
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Location: West Central Fl.
of the people, by the people, for the people. Not all people.


https://docs.google.com/file/d/0B9uKuzM ... dSYjQ/edit

I needed to enter through google account. Basicly a lawsuit against ever official in Az. that has anything to do with MM. 5 year old being denied MM after Drs. have removed 1/2 of one side of brain and cannot stop seizures. Has been prescribed a MM card by Drs. and has been taking MM and Improving . Now state saying it is hemp extract and not covered by MM laws. Lee


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Thu Nov 21, 2013 9:23 am 
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Location: NE Washington
Marijuana Compounds Can Kill Some Cancer Cells: Study

http://www.huffingtonpost.com/2013/10/2 ... 58865.html

A scientist in the United Kingdom has found that compounds derived from marijuana can kill cancerous cells found in people with leukemia, a form of cancer that is expected to cause an estimated 24,000 deaths in the United States this year.

"Cannabinoids have a complex action; it hits a number of important processes that cancers need to survive," study author Dr. Wai Liu, an oncologist at St. George's University of London, told The Huffington Post. "For that reason, it has really good potential over other drugs that only have one function. I am impressed by its activity profile, and feel it has a great future, especially if used with standard chemotherapies. ....continues


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Fri Dec 13, 2013 4:58 am 
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Banking involved again, They do not want problems so legalize Pot so they can bank money from sales,

http://news.yahoo.com/legal-pot-states- ... itics.html

Hard for U S Government to oppose banks,. Banks own the government. Lee


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Sun Jan 19, 2014 8:09 pm 
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Location: West Central Fl.
The AMA sent a letter to congress saying don't ban pot. We use it in medicines. After reading it congress went home to rest next meeting for got all about AMA. Now President says it not worse than Alcohol . 76 years . Interesting read wonder how they think now. But this was AMA what is talking now is money as Pharmaceuticals companies.

http://druglibrary.org/schaffer/hemp/taxact/t8.htm


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Fri Jan 24, 2014 7:22 am 
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Location: West Central Fl.
Hi!

I just signed the petition "President Barack Obama: If marijuana is safer than alcohol, remove it from the DEA's schedule of drugs" on Change.org.

It's important. Will you sign it too? Here's the link:

http://www.change.org/petitions/preside ... e_petition

Thanks! Lee


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Fri Jan 24, 2014 8:13 pm 
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Location: West Central Fl.
smbdyiam wrote:
hi
up date
I believe I stated some time ago that I thought in 2 years it will be legalized. Well I think probably closer to 5 years would have been closer. but it is still coming.
http://medicalmarijuana.procon.org/view ... eID=002481
Fl. has been one of the states that is hardest on use and pocession. look at section II of this and what it says about Fl. And TEXAS. Lee
Fl. could be close to 2 years earliest is 1st of July 2013 Lee


another up date
http://news.yahoo.com/florida-marijuana ... 51375.html
Vote could be this Nov Lee


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Mon Jan 27, 2014 5:42 pm 
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Location: West Central Fl.
and anther update. past another hurdle. Fl. supreme court oks wording.
http://news.yahoo.com/florida-clears-ke ... 13596.html
This has went a lot faster than I thought. I figured about 2016 now could and probably will be this Nov 2014. Lee


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Tue Jan 28, 2014 2:23 pm 
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Posts: 868
Location: NE Washington
National Cancer Institute published its findings on the evil weed

http://www.cancer.gov/cancertopics/pdq/ ... onal/page4

Laboratory/Animal/Preclinical Studies

Antitumor Effects
Appetite Stimulation
Analgesia

Cannabinoids are a group of 21-carbon–containing terpenophenolic compounds produced uniquely by Cannabis species (e.g., Cannabis sativa L.) .[1,2] These plant-derived compounds may be referred to as phytocannabinoids. Although delta-9-tetrahydrocannabinol (THC) is the primary psychoactive ingredient, other known compounds with biologic activity are cannabinol, cannabidiol (CBD), cannabichromene, cannabigerol, tetrahydrocannabivarin, and delta-8-THC. CBD, in particular, is thought to have significant analgesic and anti-inflammatory activity without the psychoactive effect (high) of delta-9-THC.

Antitumor Effects
One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.[3] During this 2-year study, groups of mice and rats were given various doses of THC by gavage. A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumors (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats. In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo .[4] In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.[5-8]

Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.[9-12] One review summarizes the molecular mechanisms of action of cannabinoids as antitumor agents.[13] Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.[14]

The effects of delta-9-THC and a synthetic agonist of the CB2 receptor were investigated in HCC.[15] Both agents reduced the viability of HCC cells in vitro and demonstrated antitumor effects in HCC subcutaneous xenografts in nude mice. The investigations documented that the anti-HCC effects are mediated by way of the CB2 receptor. Similar to findings in glioma cells, the cannabinoids were shown to trigger cell death through stimulation of an endoplasmic reticulum stress pathway that activates autophagy and promotes apoptosis. Other investigations have confirmed that CB1 and CB2 receptors may be potential targets in non-small cell lung carcinoma [16] and breast cancer.[17]

An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic, mammary cells.[18]

CBD has also been demonstrated to exert a chemopreventive effect in a mouse model of colon cancer.[19] In the experimental system, azoxymethane increased premalignant and malignant lesions in the mouse colon. Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions. In in vitro experiments involving colorectal cancer cell lines, the investigators found that CBD protected DNA from oxidative damage, increased endocannabinoid levels, and reduced cell proliferation.

Another investigation into the antitumor effects of CBD examined the role of intercellular adhesion molecule-1 (ICAM-1).[12] ICAM-1 expression has been reported to be negatively correlated with cancer metastasis. In lung cancer cell lines, CBD upregulated ICAM-1, leading to decreased cancer cell invasiveness.

In an in vivo model using severe combined immunodeficient mice, subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines.[20] Tumor growth was inhibited by 60% in THC-treated mice compared with vehicle-treated control mice. Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects. However, research with immunocompetent murine tumor models has demonstrated immunosuppression and enhanced tumor growth in mice treated with THC.[21,22]

In addition, both plant-derived and endogenous cannabinoids have been studied for anti-inflammatory effects. A mouse study demonstrated that endogenous cannabinoid system signaling is likely to provide intrinsic protection against colonic inflammation.[23] As a result, a hypothesis that phytocannabinoids and endocannabinoids may be useful in the risk reduction and treatment of colorectal cancer has been developed.[24-27]

CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.[28] In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells.

Appetite Stimulation
Many animal studies have previously demonstrated that delta-9-THC and other cannabinoids have a stimulatory effect on appetite and increase food intake. It is believed that the endogenous cannabinoid system may serve as a regulator of feeding behavior. The endogenous cannabinoid anandamide potently enhances appetite in mice.[29] Moreover, CB1 receptors in the hypothalamus may be involved in the motivational or reward aspects of eating.[30]


Analgesia
Understanding the mechanism of cannabinoid-induced analgesia has been increased through the study of cannabinoid receptors, endocannabinoids, and synthetic agonists and antagonists. The CB1 receptor is found in both the central nervous system (CNS) and in peripheral nerve terminals. Similar to opioid receptors, increased levels of the CB1 receptor are found in regions of the brain that regulate nociceptive processing.[31] CB2 receptors, located predominantly in peripheral tissue, exist at very low levels in the CNS. With the development of receptor-specific antagonists, additional information about the roles of the receptors and endogenous cannabinoids in the modulation of pain has been obtained.[32,33]

Cannabinoids may also contribute to pain modulation through an anti-inflammatory mechanism; a CB2 effect with cannabinoids acting on mast cell receptors to attenuate the release of inflammatory agents, such as histamine and serotonin, and on keratinocytes to enhance the release of analgesic opioids has been described.[34-36] One study reported that the efficacy of synthetic CB1- and CB2-receptor agonists were comparable with the efficacy of morphine in a murine model of tumor pain.[37]


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Tue Jan 28, 2014 3:10 pm 
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Posts: 1572
Location: West Central Fl.
Thank You sky.
If anybody clicks on his link look at History, Then adverse effects. Then ask self If it was declared as non medical useage back in 70"s and is a class 1 schedule drug why does U S A government hold a patent on the plant. This is the adverse effects. mostly very mild .compared to just about anything else.

Adverse Effects

Cannabis and Cannabinoids



Cannabis and Cannabinoids
Because cannabinoid receptors, unlike opioid receptors, are not located in the brainstem areas controlling respiration, lethal overdoses from Cannabis and cannabinoids do not occur.[1-4] However, cannabinoid receptors are present in other tissues throughout the body, not just in the central nervous system, and adverse effects include tachycardia, hypotension, conjunctival injection, bronchodilation, muscle relaxation, and decreased gastrointestinal motility.

Although cannabinoids are considered by some to be addictive drugs, their addictive potential is considerably lower than that of other prescribed agents or substances of abuse.[4] The brain develops a tolerance to cannabinoids.

Withdrawal symptoms such as irritability, insomnia with sleep electroencephalogram disturbance, restlessness, hot flashes, and, rarely, nausea and cramping have been observed. However, these symptoms appear to be mild compared with withdrawal symptoms associated with opiates or benzodiazepines, and the symptoms usually dissipate after a few days.

Unlike other commonly used drugs, cannabinoids are stored in adipose tissue and excreted at a low rate (half-life 1–3 days), so even abrupt cessation of cannabinoid intake is not associated with rapid declines in plasma concentrations that would precipitate severe or abrupt withdrawal symptoms or drug cravings.

Since Cannabis smoke contains many of the same components as tobacco smoke, there are valid concerns about the adverse pulmonary effects of smoked Cannabis. A longitudinal study in a noncancer population evaluated repeated measurements of pulmonary function over 20 years in 5,115 men and women whose smoking histories were known.[5] While tobacco exposure was associated with decreased pulmonary function, the investigators concluded that occasional and low-cumulative Cannabis use was not associated with adverse effects on pulmonary function (forced expiratory volume in the first second of expiration [FEV1] and forced vital capacity [FVC]).
I just know that it stops pain in wife. and the pains are always worse than the adverse effects.


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Tue Jan 28, 2014 3:27 pm 
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Posts: 1572
Location: West Central Fl.
a couple other things that I find interesting. The NCI National Cancer Institute is funded and a part of the US government.

It is not a part of the ACA american cancer association. They want the money from donations , Basically thats all they do collect donations.

Now look at important dates of NCI notice 1937 and 1971. These are also the years that Marijuana act was passed and years Nixson started war on drugs. So every time NCI found some good to Marijuana US government steps up laws against it.

The National Cancer Institute (NCI) is part of the National Institutes of Health (NIH), which is one of 11 agencies that compose the Department of Health and Human Services (HHS). The NCI, established under the National Cancer Institute Act of 1937, is the Federal Government's principal agency for cancer research and training. The National Cancer Act of 1971 broadened the scope and responsibilities of the NCI and created the National Cancer Program. Over the years, legislative amendments have maintained the NCI authorities and responsibilities and added new information dissemination mandates as well as a requirement to assess the incorporation of state-of-the-art cancer treatments into clinical practice.

The National Cancer Institute coordinates the National Cancer Program, which conducts and supports research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients. Specifically, the Institute:

Supports and coordinates research projects conducted by universities, hospitals, research foundations, and businesses throughout this country and abroad through research grants and cooperative agreements.
Conducts research in its own laboratories and clinics.
Supports education and training in fundamental sciences and clinical disciplines for participation in basic and clinical research programs and treatment programs relating to cancer through career awards, training grants, and fellowships.
Supports research projects in cancer control.
Supports a national network of cancer centers.
Collaborates with voluntary organizations and other national and foreign institutions engaged in cancer research and training activities.
Encourages and coordinates cancer research by industrial concerns where such concerns evidence a particular capability for programmatic research.
Collects and disseminates information on cancer.
Supports construction of laboratories, clinics, and related facilities necessary for cancer research through the award of construction grants.


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Fri Feb 21, 2014 11:18 pm 
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Location: NE Washington
Capitalism at its finest. :D

Girl Scout sells 117 boxes of cookies outside CA marijuana dispensary

http://fox59.com/2014/02/21/girl-scout- ... ispensary/

"SAN FRANCISCO (CNN) — Within 45 minutes of setting up outside a medical marijuana dispensary in San Francisco, California, a 13-year-old Girl Scout had to call for “back-up cookies ” — and she had so much success selling Thin Mints and Tagalongs on Monday that she’ll be back again this weekend."


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 Post subject: Re: Legalization and taxation of cannabis
PostPosted: Sun Feb 23, 2014 1:31 pm 
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Location: West Central Fl.
after getting signatures, wording right, Fl. supreme court approval, Law makers finally get on board and want laws passed even before it come to vote on ballot this Nov.

http://www.mpp.org/states/florida/alert ... -hits.html

That is politics. don't believe people emailing them but when court oks it on ballot they jump on like it is their original idea, Last I checked this morning 91% approve legalized medical Marijuana. Now some state congress men saying to legalize it before the Nov. ballot. I guess they think 91% would be a lot of votes for them. :lol: :lol: :lol:


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